Week 1 NFL Picks, Odds, 2022 Predictions, Top Expert Best Bets: This 3-Way Football Parlay Pays 6-1

The post-Ben Roethlisberger era in Pittsburgh begins as the Pittsburgh Steelers take on the reigning AFC champion Cincinnati Bengals on Sunday. With Roethlisberger retiring after last season, the Steelers are looking for their next quarterback. Mitchell Trubisky, who spent last season as a backup at Buffalo, will kick off the season opener over the first round of 2022, Kenny Pickett and backup Mason Rudolph. Cincinnati is favorite with 6.5 points in Caesars Sportsbook’s latest NFL odds, but which side should you lean on with your NFL parlays? The game is one of 16 on a loaded Week 1 NFL schedule. Other key NFL matchups include the Cowboys and Buccaneers going head to head in a rematch of last season’s Week 1 classic and Panthers quarterback Baker Mayfield against his former team, the Browns. Before making any NFL picks or predictions for Week 1, check out SportsLine’s best NFL bets from Larry Hartstein.

A former lead writer for Covers and The Linemakers, Hartstein combines an extensive network of Vegas resources with an analytical approach he honed while working for Pro Football Focus. Going into the 2022 NFL season, he is 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 at the spread.

Hartstein went on to play 68-50 ATS and 8-3 on the money-line last season for a profit of $1,552. His picks are only available on SportsLine and on the Early Edge. Anyone who has followed him consistently is at the very top.

Now Hartstein has pinned his confident picks for three Week 1 games, and he has a parlay that would make it 6-1. You can only see his Week 1 NFL picks on SportsLine.

Top Picks from NFL Experts in Week 1

After closely studying all 16 games from Week 1, Hartstein loves the Chargers (-3) to protect himself from the Raiders. Los Angeles solved its biggest problem, the run defense, offseason by adding Khalil Mack, Sebastian Joseph-Day, Austin Johnson and Morgan Fox to bolster their front. Los Angeles could have as many as four new starters in a defense that gave up 138.9 rushing yards per game last season, the third most in the NFL.

Plus, the Chargers have one of the NFL’s most versatile weapons in Austin Ekeler. Last season, the 5-foot-10, 200-pound running back had four games with at least one rushing touchdown and one receiving touchdown. He is the first player since Christian McCaffrey in 2019 and only the third player in the past 20 seasons to achieve that feat. Check out who else to pick in week 1 here.

How to Make NFL Parlays in Week 1

Hartstein has also landed two other spread picks, including a game that blurs a team that “could struggle at the beginning.” You can only see Hartstein’s full analysis and picks for his Week 1 NFL parlay here.

So which teams should you target in a three-way parlay for a 6-1 payout? And which team is a must-fade? Visit SportsLine now to see Larry Hartstein’s week 1 three-way parlay, all of the expert’s up over $3,700, and find out.